Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 56, Issue 11, Pages 6021-6025Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01484-12
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Funding
- Paul Ehrlich foundation
- Federal Ministry of Education and Research (BMBF), Germany [FKZ 01EO1002, FKZ 01KI1204]
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Since cations have been reported as essential regulators of biofilm, we investigated the potential of the broad-spectrum antimicrobial and cation-chelator nitroxoline as an antibiofilm agent. Biofilm mass synthesis was reduced by up to 80% at sub-MIC nitroxoline concentrations in Pseudomonas aeruginosa, and structures formed were reticulate rather than compact. In preformed biofilms, viable cell counts were reduced by 4 logs at therapeutic concentrations. Complexation of iron and zinc was demonstrated to underlie nitroxoline's potent antibiofilm activity.
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