Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 56, Issue 6, Pages 3399-3401Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.06425-11
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- University of Pittsburgh
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We have developed a robust cytopathic effect-based high-throughput screening assay to identify inhibitors of dengue virus (DENY) infection. Screening of a small natural product library yielded 11 hits. Four of these were found to be potent inhibitors of DENY, although serotype differences were noted. Taken together, these data suggest that screening of larger and more complex molecule libraries may result in the identification of more potent and specific DENV inhibitors.
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