Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 56, Issue 4, Pages 2191-2193Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.05856-11
Keywords
-
Categories
Funding
- Grants-in-Aid for Scientific Research [22405038, 23658235, 22380155] Funding Source: KAKEN
Ask authors/readers for more resources
T-2307, a novel arylamidine, has been shown to exhibit broad-spectrum antifungal activities against clinically significant pathogens. Here, we evaluated the in vitro and in vivo antimalarial activity of T-2307. The 50% inhibitory concentrations (IC(50)s) of T-2307 against Plasmodium fakiparum FCR-3 and K-1 strains were 0.47 and 0.17 mu M, respectively. T-2307 at 2.5 to 10 mg/kg of body weight/day exhibited activity against blood stage and liver stage parasites in rodent malaria models. In conclusion, T-2307 exhibited in vitro and in vivo antimalarial activity.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available