Journal
CANCER LETTERS
Volume 228, Issue 1-2, Pages 71-81Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2004.12.056
Keywords
neuroblastoma; array CGH; microarray; tumor evolution; DNA copy number; genornic alteration; amplification; MYCN
Categories
Ask authors/readers for more resources
Neuroblastoma (NB) is one of the most common pediatric solid tumors and displays a broad variety of genomic alterations. Array-based comparative genomic hybridization (A-CGH) is a novel technology enabling the high-resolution detection of DNA copy number aberrations. In this article, we outline features of this new technology and approaches of data analysis. We focus on stage specific DNA copy number variations in neuroblastoma detected by cDNA array-based comparative genomic hybridization (A-CGH). We also discuss hypothetic evolutionary models of neuroblastoma progression that can be derived from A-CGH data. Published by Elsevier Ireland Ltd.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available