Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 5, Pages 2438-2441Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01549-10
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Funding
- Institut Pasteur
- Centre National de la Recherche Scientifique [CNRS-URA 2171]
- French National Research Agency [ANR-08-MIE-016]
- EU (NoE Euro-PathoGenomics) [LSHB-CT-2005-512061]
- Fondation pour la Recherche Medicale (equipe FRM)
- Roux Foundation
- Conseil regional d'Ile-de-France
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Antibiotic resistance development has been linked to the bacterial SOS stress response. In Escherichia coli, fluoroquinolones are known to induce SOS, whereas other antibiotics, such as aminoglycosides, tetracycline, and chloramphenicol, do not. Here we address whether various antibiotics induce SOS in Vibrio cholerae. Reporter green fluorescent protein (GFP) fusions were used to measure the response of SOS-regulated promoters to subinhibitory concentrations of antibiotics. We show that unlike the situation with E. coli, all these antibiotics induce SOS in V. cholerae.
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