Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 9, Pages 4398-4401Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00329-11
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- Departament de Universitats, Recerca i Societat de la Informacio de la Generalitat d'Catalunya [2009 SGR 1256]
- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III, Spanish Network for the Research in Infectious Disease [REIPI 06/0008]
- European Community [HEALTH-F3-2008-223031]
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Twenty Klebsiella pneumoniae isolates producing OXA-48 were collected from April 2009 to September 2010. Strains were clonally related and coproduced a CTX-M-15 beta-lactamase. A conjugative plasmid of circa 70 kb carrying bla OXA-48 was identified. Eleven isolates showed low-level resistance to carbapenems, whereas nine showed high-level resistance. Decreased expression of OmpK36 was related to high-level resistance to carbapenems. The isolates belonged to sequence type 101 (ST101). This is the first outbreak caused by an OXA-48-producing K. pneumoniae strain in Spain.
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