Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 6, Pages 3022-3024Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01732-10
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Funding
- Australian National Health and Medical Research Council
- Australian Postgraduate Award scholarship
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Infections caused by Acinetobacter baumannii are of increasing concern, largely due to the multidrug resistance of many strains. Here we show that insertion sequence ISAba11 movement can result in inactivation of the A. baumannii lipid A biosynthesis genes lpxA and lpxC, resulting in the complete loss of lipopolysaccharide production and high-level colistin resistance.
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