Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 5, Pages 2420-2423Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01452-10
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Funding
- INSERM, France
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539]
- Universite Paris XI, Paris
- European Community (TEMPOtest-QC) [HEALTH-2009-241742]
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Seventeen Klebsiella pneumoniae isolates producing the OXA-48 carbapenemase, obtained from 10 patients hospitalized from April to June 2010, mostly in the medical intensive care unit of the Villeneuve-Saint-Georges Hospital in a suburb of Paris, France, were analyzed. Seven patients were infected, of whom five were treated at least with a carbapenem, and five patients died. Molecular analysis showed that the isolates belonged to a single clone that harbored a 70-kb plasmid carrying the bla(OXA-48) gene and coproduced CTX-M-15 and TEM-1 beta-lactamases. This is the first reported outbreak of OXA-48-producing K. pneumoniae isolates in France.
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