Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 7, Pages 3616-3620Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01682-10
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- Novexel, Romainville, France
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NXL104, a novel beta-lactamase inhibitor, was tested at a constant concentration of 4 mu g/ml in combination with ceftazidime (CAZ), with and without added metronidazole, against 396 beta-lactamase-producing strains of anaerobic bacteria. MIC(50)/MIC(90) values for Bacteroides fragilis and the B. fragilis group were 8/16 and 64/>128 mu g/ml, respectively. Although CAZ-NXL104 had limited activity against most anaerobic strains, in combination with metronidazole it shows potential for treating mixed infections involving resistant Enterobacteriaceae and anaerobes.
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