Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 5, Pages 2413-2416Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01742-10
Keywords
-
Categories
Funding
- United Kingdom Medical Research Council [G0600810]
- United Kingdom Biological and Biosciences Research Council
- MRC [G0600810] Funding Source: UKRI
- Medical Research Council [G0600810] Funding Source: researchfish
Ask authors/readers for more resources
We explored the properties of corallopyronin A (CorA), a poorly characterized inhibitor of bacterial RNA polymerase (RNAP). It displayed a 50% inhibitory concentration of 0.73 mu M against RNAP, compared with 11.5 nM for rifampin. The antibacterial activity of CorA was also inferior to rifampin, and resistant mutants of Staphylococcus aureus were easily selected. The mutations conferring resistance resided in the rpoB and rpoC subunits of RNAP. We conclude that CorA is not a promising antibacterial drug candidate.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available