Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 11, Pages 5358-5361Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00690-11
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Funding
- Institut de Veille Sanitaire
- Institut Pasteur
- Merck
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Infections due to caspofungin-resistant Candida isolates in patients exposed to caspofungin therapy are increasing. We report here a nested case-control study which aimed at identifying factors associated with bloodstream infections caused by Candida spp. having reduced susceptibility to caspofungin (CRSC) in adults suffering from hematological malignancies. In univariate and multivariate analyses, infections with CRSC were associated with caspofungin exposure in the previous 30 days (odds ratio [OR] = 5.25; 95% confidence interval [95% CI], 1.68-16.35) and with an age of <= 65 years (OR = 3.27; 95% CI, 1.26-8.50).
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