Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 4, Pages 1792-1793Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01403-10
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- Inserm
- Vaincre La Mucoviscidose
- UPMC Univ. Paris [06]
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Azithromycin (AZM) has shown promising anti-inflammatory properties in chronic obstructive pulmonary diseases, and clinical studies have presented an improvement in the respiratory condition of cystic fibrosis (CF) patients. The aim of this study was to investigate, in human airway cells, the mechanism by which AZM has beneficial effects in CF. We demonstrated that AZM did not have any anti-inflammatory effect on CF airway cells but restored Cl- efflux.
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