Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 11, Pages 5354-5357Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00507-11
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Funding
- Chinese Scholarship Council
- Nederlandse Organisatie voor Wetenschappelijk Onderzoek [700.55.017]
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Pyrazinoic acid, the active form of the first-line antituberculosis drug pyrazinamide, decreased the proton motive force and respiratory ATP synthesis rates in subcellular mycobacterial membrane assays. Pyrazinoic acid also significantly lowered cellular ATP levels in Mycobacterium bovis BCG. These results indicate that the predominant mechanism of killing by this drug may operate by depletion of cellular ATP reserves.
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