Journal
SCIENCE
Volume 310, Issue 5748, Pages 676-679Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1118391
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Funding
- FIC NIH HHS [R01-TW05869] Funding Source: Medline
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Severe acute respiratory syndrome (SARS) emerged in 2002 to 2003 in southern China. The origin of its etiological agent, the SARS coronavirus (SARS-CoV), remains elusive. Here we report that species of bats are a natural host of coronaviruses closely related to those responsible for the SARS, outbreak. These viruses, termed SARS-like coronaviruses (SL-CoVs), display greater genetic variation than SARS-CoV isolated from humans or from civets. The human and civet isolates of SARS-CoV nestle phylogenetically within the spectrum of SL-CoVs, indicating that the virus responsible for the SARS outbreak Was a member of this coronavirus group.
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