Journal
MOLECULAR BRAIN RESEARCH
Volume 140, Issue 1-2, Pages 142-149Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molbrainres.2005.07.011
Keywords
phencyclidine; methamphetamine; schizophrenia; serial analysis of gene expression (SAGE); cerebral cortex
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Both phencyclidine (PCP) and methamphetamine (MAP) can cause schizophrenia-like symptoms. To identify the molecules relating to the drug-induced psychotic state, we used serial analysis of gene expression in rodent cerebral cortices isolated 1 h after intraperitoneal injection of saline, PCP (10 mg/kg), or MAP (4 mg/kg). We analyzed a total of 150,000 tags and found significantly up- or down-regulated genes. The number of MAP-, PCP-, and MAP and PCP-reactive tags were 229, 215, and 41, respectively. (c) 2005 Elsevier B.V. All rights reserved.
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