Journal
FEBS LETTERS
Volume 579, Issue 26, Pages 5950-5957Publisher
WILEY
DOI: 10.1016/j.febslet.2005.08.016
Keywords
RNA silencing; quelling; meiotic silencing by unpaired DNA; dicer
Funding
- Wellcome Trust Funding Source: Medline
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Two RNA silencing-related phenomena, quelling and meiotic silencing by impaired DNA (MSUD) have been identified in the fungus Neurospora crassa. Similar to the case with the siRNA and miRNA pathways in Drosophila, different sets of protein components including RNA-dependent RNA polymerase, argonaute and dicer, are used in the quelling and MSUD pathways. Orthologs of the RNA silencing components are found in most, but not all, fungal genomes currently available in the public databases, indicating that the majority of fungi possess the silencing machinery. Advantage and disadvantage of RNA silencing as a tool to explore gene function in fungi are discussed. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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