Journal
FEBS LETTERS
Volume 579, Issue 26, Pages 5822-5829Publisher
WILEY
DOI: 10.1016/j.febslet.2005.08.079
Keywords
RNA interference; miRNA; microRNA; dicer; drosha; argonaute; slicer; RNA-induced silencing complex
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RNA interference (RNAi) is broadly defined as a gene silencing pathway that is triggered by double-stranded RNA (dsRNA). Many variations have been described on this theme. The dsRNA trigger can be supplied exogenously, as an experimental tool, or can derive from the genome in the form of microRNAs. Gene silencing can be the result of nucleolytic degradation of the mRNA, or by translational suppression. At the heart of the pathway are two ribonuclease machines. The ribonuclease III enzyme Dicer initiates the RNAi pathway by generating the active short interfering RNA trigger. Silencing is effected by the RNA-induced silencing complex and its RNaseH core enzyme Argonaute. This review describes the discovery of these machines and discusses future lines of work on this amazing biochemical pathway. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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