Journal
FEBS LETTERS
Volume 579, Issue 26, Pages 5830-5840Publisher
WILEY
DOI: 10.1016/j.febslet.2005.08.009
Keywords
microRNA; miRNA; small interfering RNA; siRNA
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Double-stranded RNA (dsRNA) is a potent trigger of sequence-specific gene silencing mechanisms known as RNA silencing or RNA interference. The recognition of the target sequences is mediated by ribonucleoprotein complexes that contain 21- to 28-nucleotide (nt) guide RNAs derived from processing of the trigger dsRNA. Here, we review the experimental and bioinformatic approaches that were used to identify and characterize these small RNAs isolated from cells and tissues. The identification and characterization of small RNAs and their expression patterns is important for elucidating gene regulatory networks. (c) 2005 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
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