Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 54, Issue 5, Pages 2252-2257Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01074-09
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Funding
- Fondo de Investigacion Sanitaria (FIS), Government of Spain [2006/0002]
- FUNCIS [FUNCIS50/05]
- Canary Islands Autonomous Government
- FIS-SCS
- National Health and Medical Research Council of Australia [4571029]
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We have sequenced the conjugative plasmid pPR9, which carries the ileS2 gene, which had contributed to the dissemination of high-level mupirocin resistance at our institution. The plasmid backbone shows extensive genetic conservation with plasmids belonging to the pSK41/pGO1 family, but comparative analyses have revealed key differences that provide important insights into the evolution of these medically important plasmids and high-level mupirocin resistance in staphylococci and highlight the role of insertion sequence IS257 in these processes.
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