Journal
FEMS MICROBIOLOGY REVIEWS
Volume 29, Issue 5, Pages 949-959Publisher
WILEY-BLACKWELL
DOI: 10.1016/j.femsre.2005.03.002
Keywords
chlamydia; prokaryotic development; microarray analysis
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Funding
- NHLBI NIH HHS [R01 HL071735, HL 71735-02] Funding Source: Medline
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Intracellular parasitism by bacterial pathogens is a complex, multi-factorial process that has been exploited successfully by a wide variety of organisms. Members of the Order Chlamydiales are obligate intracellular bacteria that are transmitted as metabolically inactive particles and must differentiate, replicate, and re-differentiate within the host cell to carry out their life cycle. Understanding the developmental cycle has been greatly advanced by the availability of complete genome sequences, DNA microarrays, and advanced cell biology techniques. Measuring transcriptional changes throughout the cycle has allowed investigators to determine the nature of the temporal gene expression changes required for bacterial growth and development. (c) 2005 Published by Elsevier B.V. on behalf of the Federation of European Microbiological Societies.
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