Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 3, Pages 1266-1269Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00927-10
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Funding
- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III [PI060580]
- Consejeria de Innovacion Ciencia y Empresa, Junta de Andalucia, Spain [P07-CTS-02908]
- Ministerio de Sanidad y Consumo, Instituto de Salud Carlos III-FEDER, Spanish Network for Research in Infectious Diseases [REIPI RD06/0008]
- Instituto de Salud Carlos III (PFIS), Spain
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This article provides an analysis of the in vitro effect of qnrA1, qnrB1, and qnrS1 genes, combined with quinolone-resistant Ser83Leu substitutions in GyrA and/or Ser80Arg in ParC, on fluoroquinolone (FQ) resistance in isogenic Escherichia coli strains. The association of Ser83Leu substitution in GyrA, Ser80Arg substitution in ParC, and qnr gene expression increased the MIC of ciprofloxacin to 2 mu g/ml. qnr genes present in E. coli that harbored a Ser83Leu substitution in GyrA increased mutant prevention concentration (MPC) values to 8 to 32 mu g/ml. qnr gene expression in E. coli may play an important role in selecting for one-step FQ-resistant mutants.
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