Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 54, Issue 4, Pages 1639-1643Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01364-09
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Funding
- Japanese Ministry of Education, Culture, Sports, Science and Technology [19790324, 21390305]
- Global Centers of Excellence Programs, Nagasaki University
- Ministry of Health, Labor and Welfare [H20-nanchi-ippan-035, H20-shinko-ippan-012, H20-shinko-ippan-015]
- Grants-in-Aid for Scientific Research [19790324] Funding Source: KAKEN
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A Candida glabrata calcineurin mutant exhibited increased susceptibility to both azole antifungal and cell wall-damaging agents and was also attenuated in virulence. Although a mutant lacking the downstream transcription factor Crz1 displayed a cell wall-associated phenotype intermediate to that of the calcineurin mutant and was modestly attenuated in virulence, it did not show increased azole susceptibility. These results suggest that calcineurin regulates both Crz1-dependent and -independent pathways depending on the type of stress.
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