Journal
CURRENT ANALYTICAL CHEMISTRY
Volume 1, Issue 3, Pages 223-240Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/157341105774573929
Keywords
mass spectrometry; sulfated carbohydrates; glycosaminoglycan; oligosaccharide; structure; sequence
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Funding
- NIGMS NIH HHS [R01 GM038060] Funding Source: Medline
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Sulfated polysaccharides and their oligosaccharide components play an important biological role in physiological and pathophysiological processes. Glycosaminoglycans, such as heparin, are currently used as pharmaceutical agents to control coagulation. Moreover, there are intensive efforts in developing rapid approaches for the analysis of such bioactive carbohydrates to assess their pharmacological activity and in glycomic applications. Soft ionization methods of mass spectrometry have been applied with recent success in the analysis of sulfated carbohydrates. This review will examine the application of mass spectrometry in the compositional analysis and structural characterization of these important highly charged molecules.
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