Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 54, Issue 3, Pages 1323-1326Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00812-09
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Funding
- Swiss National Science Foundation [310030-116257]
- Cubist Pharmaceuticals
- Lexington
- MA
- Novartis Pharma Schweiz
- AG
- Bern
- Switzerland
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Antibiotic-induced bacteriolysis exacerbates inflammation and brain damage in bacterial meningitis. Here the quality and temporal kinetics of cerebrospinal fluid (CSF) inflammation were assessed in an infant rat pneumococcal meningitis model for the nonbacteriolytic antibiotic daptomycin versus ceftriaxone. Daptomycin led to lower CSF concentrations of interleukin 1 beta (IL-1 beta), IL-10, IL-18, monocyte chemoattractant protein 1 (MCP-1), and macrophage inflammatory protein 1 alpha (MIP-1 alpha) (P < 0.05). In experimental pneumococcal meningitis, daptomycin treatment resulted in more rapid bacterial killing, lower CSF inflammation, and less brain damage than ceftriaxone treatment.
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