Journal
NATURE STRUCTURAL & MOLECULAR BIOLOGY
Volume 12, Issue 11, Pages 952-957Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/nsmb1005
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Funding
- NIGMS NIH HHS [GM-53491, GM-53320] Funding Source: Medline
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As a counter-defense against antiviral RNA silencing during infection, the insect Flock House virus (FHV) expresses the silencing suppressor protein B2. Biochemical experiments show that B2 binds to double-stranded RNA (dsRNA) without regard to length and inhibits cleavage of dsRNA by Dicer in vitro. A cocrystal structure reveals that a B2 dimer forms a four-helix bundle that binds to one face of an A-form RNA duplex independently of sequence. These results suggest that B2 blocks both cleavage of the FHV genome by Dicer and incorporation of FHV small interfering RNAs into the RNA-induced silencing complex.
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