Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 54, Issue 5, Pages 2239-2243Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01677-09
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Funding
- Asahi Glass Foundation
- Astellas Foundation for Research on Metabolic Disorders
- Nakajima Foundation
- Senri Life Science Foundation
- Takeda Science Foundation
- Uehara Memorial Foundation
- National Institute of Biomedical Innovation
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- Japan Society for the Promotion of Science
- PRESTO, Japan Science and Technology Agency
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NlpE, an outer membrane lipoprotein, functions during envelope stress responses in Gram-negative bacteria. In this study, we report that overproduction of NlpE increases multidrug and copper resistance through activation of the genes encoding the AcrD and MdtABC multidrug efflux pumps in Escherichia coli.
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