Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 55, Issue 3, Pages 1256-1261Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00921-10
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Funding
- INSERM [U914]
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA 3539]
- Universite Paris XI, Paris, France
- European Community [HEALTH-F3-2008-223031, HEALTH-2009-241742]
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Environmental Aeromonas sp. isolates resistant to ceftazidime were recovered during an environmental survey performed with water samples from the Seine River, in Paris, France, in November 2009. Selected isolates were identified by sequencing of the 16S rRNA and rpoB genes. PCR and cloning experiments were used to identify broad-spectrum-beta-lactamase-encoding genes and their genetic context. Clavulanic acid-inhibited extended-spectrum-beta-lactamase (ESBL) genes were identified in 71% of the Aeromonas sp. isolates. A variety of ESBL genes were detected, including bla(VEB-1a), bla(SHV-12), bla(PER-1), bla(PER-6), bla(TLA-2), and bla(GES-7), suggesting an aquatic reservoir of those ESBL genes. Moreover, the repeated elements and different insertion sequences were identified in association with the bla(PER-6) and the bla(VEB-1a) genes, respectively, indicating a wide diversity of mobilization events, making Aeromonas spp. a vehicle for ESBL dissemination.
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