Journal
ARCHIVES OF MICROBIOLOGY
Volume 184, Issue 3, Pages 152-157Publisher
SPRINGER
DOI: 10.1007/s00203-005-0037-9
Keywords
salicylate; microarray; gene regulation; Mycobacterium tuberculosis
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Funding
- NIAID NIH HHS [AI-44063] Funding Source: Medline
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Salicylate stimulates the oxygen consumption and also induces multiple drug resistance in Mycobacterium tuberculosis. To gain insight into the mechanisms involved in the above observations, a microarray analysis of M. tuberculosis genes in response to salicylate was performed. Salicylate, besides highly inducing the 27 kD gene (Rv0560c) previously identified as highly salicylate-inducible, also caused increased transcription of a range of genes including an open reading frame (Rv0559c) that is located immediately downstream of the 27 kD gene, and some membrane/transmembrane proteins that may serve as potential efflux pumps or porins. Salicylate also caused a general shutdown of transcription and translation and energy production by down-regulating a range of genes involved in RNA and protein synthesis and ATP synthesis. The role of the salicylate-regulated genes in salicylate induced drug resistance and its unique effect on stimulating oxygen consumption in tubercle bacillus is discussed.
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