Journal
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
Volume 63, Issue 3, Pages 655-666Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.ijrobp.2005.06.032
Keywords
ionizing radiation; immunotherapy; cross-priming; tumor-associated antigens
Funding
- NCI NIH HHS [K08 CA089336, R01 CA-101752, 5 P30 CA16087-25, R01 CA101752, K08 CA89336, P30 CA016087] Funding Source: Medline
- NIAID NIH HHS [AI061684, R01 AI061684] Funding Source: Medline
- PHS HHS [52731] Funding Source: Medline
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Ionizing radiation therapy (RT) is an important local modality for the treatment of cancer. The current rationale for its use is based largely on the ability of RT to kill the cancer cells by a direct cytotoxic effect. Nevertheless, considerable evidence indicates that RT effects extend beyond the mere elimination of the more radiosensitive fraction of cancer cells present within a tumor at the time of radiation exposure. For instance, a large body of evidence is accumulating on the ability of RT to modify the tumor microenvironment and generate inflammation. This might have far-reaching consequences regarding the response of a patient to treatment, especially if radiation-induced tumor cell kill were to translate into the generation of effective antitumor immunity. Although much remains to be learned about how radiation can impact tumor immunogenicity, data from preclinical studies provide the proof of principle that different immunotherapeutic strategies can be combined with RT to enhance antitumor effects. Conversely, RT could be a useful tool to combine with immunotherapy. This article will briefly summarize what is known about the impact of RT on tumor immunity, including tumor-associated antigens, antigen-presenting cells, and effector mechanisms. In addition, the experimental evidence supporting the contention that RT can be used as a tool to induce antitumor immunity is discussed, and a new approach to radioimmunotherapy of cancer is proposed. (c) 2005 Elsevier Inc.
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