Journal
BIOMARKERS
Volume 10, Issue 6, Pages 456-463Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13547500500399979
Keywords
serum bile acids; organic solvents; biological monitoring; liver injury
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The objective was to evaluate total serum bile acids (SBA) as a biological marker of hepatotoxicity in car painters exposed to organic solvents and to compare their performance with classic biochemical parameters of liver function. SBA were analysed in a selected group of workers (n = 57) occupationally exposed to a mixture of organic solvents and in a control group ( n = 51). In addition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), total bilirubin ( TB), gamma-glutamyltransferase (GGT) and alkaline phosphatase ( ALP) were determined in the two groups. Urinary hippuric acid was measured in all samples. Statistical analysis of the data revealed a significant increase in the concentration of SBA, AST, ALP and TB in exposed workers compared with controls ( Mann - Whitney, p <= 0.05). However, SBA was the parameter most frequently altered in exposed workers and showed higher significance between the two groups (chi-square test) compared with the upper limit of the reference range ( 8 mu mol l(-1)). In conclusion, SBA can be considered to be a sensitive parameter of hepatotoxicity induced by organic solvents than the traditional tests and it can be used as an biological marker of subclinical liver injury.
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