Journal
JOURNAL OF VIROLOGY
Volume 79, Issue 22, Pages 14451-14456Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.79.22.14451-14456.2005
Keywords
-
Categories
Ask authors/readers for more resources
Only a relatively few mutations in its spike protein allow the murine coronavirus to switch from a murine-restricted tropism to an extended host range by being passaged in vitro. One such virus that we studied had acquired two putative heparan sulfate-binding sites while preserving another site in the furin-cleavage motif. The adaptation of the virus through the use of heparan sulfate as an attachment/entry receptor was demonstrated by increased heparin binding as well as by inhibition of infection through treatment of cells and the virus with heparinase and heparin, respectively.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available