Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 54, Issue 8, Pages 3516-3519Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01756-09
Keywords
-
Categories
Funding
- NIH [AI 070829, AI 062755]
- VA Merit Award
- VA Medical Research Service
Ask authors/readers for more resources
Macrolide resistance is a major concern in the treatment of Streptococcus pneumoniae. Inducible macrolide resistance in this pneumococcus is mediated by the efflux pump MefE/Mel. We show here that the human antimicrobial peptide LL-37 induces the mefE promoter and confers resistance to erythromycin and LL-37. Such induction may impact the efficacy of host defenses and of macrolide-based treatment of pneumococcal disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available