Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 10, Pages 4533-4536Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00519-09
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Funding
- Medicines for Malaria Venture (Geneva, Switzerland)
- NIH [HL077632]
- Juvenile Diabetes Research Foundation
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Murine models of Plasmodium falciparum malaria may become crucial tools in drug discovery. Here we show that non-myelodepleted NOD-scid IL2R gamma(null) mice engrafted with human erythrocytes support an infectious burden up to tenfold higher than that supported by engrafted NOD-scid beta 2microglobulin(null) mice. The new model was validated for drug discovery and was used to assess the therapeutic efficacy of 4-pyridones, selective inhibitors of P. falciparum cytochrome bc(1).
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