Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 6, Pages 2636-2637Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01415-08
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Funding
- National Institutes of Health [AI-39108]
- Swiss National Science Foundation [3100A0-112370/1, 3100A0-116075]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI039108] Funding Source: NIH RePORTER
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We used a well-characterized isogenic set of clinical bloodstream Staphylococcus aureus strains to study (i) regulation of mprF-mediated phosphatidylglycerol lysinylation in the contexts of in vitro daptomycin (DAP) nonsuceptibility and (ii) the role of mprF mutation in endovascular virulence. We observed a correlation between increased expression of a mutant mprF gene and reduced in vitro DAP susceptibility. There were no detectable fitness differences between strains in experimental infective endocarditis.
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