Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 7, Pages 3170-3172Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00177-09
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Funding
- Key Project of Chinese National Programs [2008ZX10003-010]
- Key Project of Chinese National Programs for Fundamental Research and Development ( 973 Program) [2005CB523102]
- Chinese National Programs 863 [2006AA02 Z423]
- National Institutes of Health [D43 TW007887]
- TB-VIR network
- European Commission [200973]
- MRC [MC_U117588500] Funding Source: UKRI
- Medical Research Council [MC_U117588500] Funding Source: researchfish
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We determined the prevalence of fluoroquinolone resistance among the isolates of Mycobacterium tuberculosis from 605 pulmonary tuberculosis patients in Shanghai, China. Mutations in gyrA were found in 81.5% of phenotypically fluoroquinolone-resistant isolates and were used as a molecular marker of fluoroquinolone resistance. gyrA mutations were detected in 1.9% of strains pan-susceptible to first-line drugs and 25.1% of multidrug-resistant strains. Fluoroquinolone resistance was independently associated with resistance to at least one first-line drug and prior tuberculosis treatment.
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