Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 8, Pages 3592-3594Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00471-09
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Funding
- Government of the Hong Kong SAR University Grants Committee Areas of Excellence Fund, Medicines for Malaria Venture and Bayer AG
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Artemisone (single oral dose, 10 mg/kg of body weight) cured nonimmune Aotus monkeys of their Plasmodium falciparum infections when combined with mefloquine (single oral dose, 5 and 10 mg/kg but not 2.5 mg/kg). In combination with amodiaquine (20 mg/kg/day), artemisone (10 mg/kg/day) given orally for 3 days cured all infected monkeys. Three days of treatment with artemisone (30 mg/kg/day) and clindamycin (100 mg/kg/day) was also curative.
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