Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 54, Issue 1, Pages 530-532Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01136-09
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- Fondo de Investigaciones Sanitarias
- Ministerio de Sanidad y Consumo of Spain [PI 050031]
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We evaluated the efficacy of posaconazole against Candida tropicalis in a systemic infection model with immunosuppressed mice. Posaconazole at 50 mg/kg of body weight/day prolonged the survival of mice and reduced the fungal tissue burden of mice infected with any of the five strains tested, with the exception of one strain that had a high MIC against this drug. Our results demonstrate the efficacy of posaconazole in the treatment of invasive murine infection caused by C. tropicalis.
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