Journal
MAGNETIC RESONANCE IN MEDICINE
Volume 54, Issue 5, Pages 1194-1206Publisher
WILEY
DOI: 10.1002/mrm.20667
Keywords
diffusion tensor; fiber distribution; q-ball imaging; high angular resolution diffusion imaging; partial volume averaging
Funding
- NIBIB NIH HHS [1R01-EB002777] Funding Source: Medline
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High angular resolution measurements of diffusion are used to estimate the angular distribution and diffusion anisotropy of fibers in a voxel. A simple, axially symmetric model of diffusion in white matter fibers is used to relate diffusion measurements to fiber properties. The new technique is called fiber orientation estimated using continuous axially symmetric tensors (FORECAST). It is tested using both numerical simulation and in vivo measurements. The new method agrees with other methods in voxels containing single fibers, but resolves crossing fibers better, at least at the level of diffusion weighting used in this study (tr(b) = 1480 s/mm(2)). The simplifying assumptions of the model are tested by comparison with the model-free q-ball analysis of in vivo data and the results are shown to be in good agreement. The new method addresses the problem of partial volume averaging in diffusion tensor imaging and provides a basis for more reliable estimates of fiber orientation and fractional anisotropy. Magn Reson Med 54:1194-1206, 2005. (c) 2005 Wiley-Liss, Inc.
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