Journal
BONE
Volume 37, Issue 5, Pages 601-606Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.bone.2005.06.002
Keywords
interleukin-6; interteukin-6 soluble receptor; osteoblasts; bone formation
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Interleukin (IL)-6 has long been considered as an osteoresorptive factor. However, recent data indicate that IL-6 could influence bone formation in conditions of increased bone turnover. In this paper, the effects of IL-6 and its soluble receptor on osteoblast proliferation, differentiation and apoptosis are readdressed. A brief summary of IL-6 signaling after binding to its receptor is provided and hypotheses concerning IL-6 and the central control of bone formation are also highlighted. (c) 2005 Elsevier Inc. All rights reserved.
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