4.7 Article

ISCR2, Another Vehicle for blaVEB Gene Acquisition

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 11, Pages 4940-4943

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00414-09

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Funding

  1. Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539]
  2. Universite Paris XI, Paris, France
  3. European Community [LSHM-CT-2005-018705, HEALTH-F3-2008-223031]
  4. INSERM

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The expanded-spectrum beta-lactamase (ESBL) gene bla(VEB-1), identified worldwide in Enterobacteriaceae and Pseudomonas aeruginosa, is associated with either class 1 integrons or repeated elements. We report here the first association of bla(VEB-1a) with the insertion sequence ISCR2 in six Acinetobacter species isolates recovered from Argentina. That genetic structure was likely at the origin of the mobilization of this ESBL gene.

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