Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 6, Pages 2657-2659Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01663-08
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- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539,]
- European Community [LSHM-CT-2005-018705]
- INSERM
- Fonds d'Etude et de Recherche du Corps Medical des Hopitaux de Paris, Paris, France
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Two clonally related Acinetobacter baumannii isolates, A1 and A2, were obtained from the same patient. Isolate A2, selected after an imipenem-containing treatment, showed reduced susceptibility to carbapenems. This resistance pattern was related to insertion of the ISAba1 element upstream of the naturally occurring bla(OXA-66) carbapenemase gene as demonstrated by sequencing, reverse transcription-PCR analysis, and inactivation of the bla(OXA-66) gene.
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