Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 3, Pages 1231-1234Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.01173-08
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Funding
- Ministry of Education, Science, Sports, Culture and Technology of Japan [18590438]
- Grants-in-Aid for Scientific Research [18590438] Funding Source: KAKEN
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We describe here the genetic analysis of a vancomycin-susceptible Staphylococcus aureus (VSSA) strain, Mu50 Omega, a strain related to vancomycin-intermediate S. aureus (VISA) strain Mu50. Using a combination of Mu50 Omega whole-genome sequencing and genome engineering, we observed a stepwise evolution of vancomycin resistance from VSSA to VISA after the mutated vraS and graR genes of Mu50 were engineered into Mu50 Omega.
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