Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 9, Pages 3985-3988Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00009-09
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Funding
- NSF [DMR-0312046]
- Virginia Tech's Institute for Critical and Applied Technologies (ICTAS)
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Nanostructures encapsulating gentamicin and having either amphiphilic (N1) or hydrophilic (N2) surfaces were designed. Flow cytometry and confocal microscopy studies demonstrated a higher rate of uptake for amphiphilic surfaces. A majority of N1 were localized in the cytoplasm, whereas N2 colocalized with the endosomes/lysosomes. Colocalization was not observed between nanostructures and intracellular Salmonella bacteria. However, significant in vitro reductions in bacterial counts (0.44 log(10)) were observed after incubation with N1, suggesting that the surface property of the nanostructure influences intracellular bacterial clearance.
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