Journal
CELL DEATH AND DIFFERENTIATION
Volume 12, Issue -, Pages 1490-1496Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cdd.4401607
Keywords
cytochrome; apoptosis
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Here we review recent observations indicating the existence of redundant cell death mechanisms. We speculate that this redundancy reflects a particular evolutionary history for cellular demise. Autophagic or apoptotic elements might have been added to a primordial death mechanism, initially improving cell dismantling and later acquiring the ability to act themselves as death effectors. The resulting redundancy of cell death mechanisms has pathophysiological implications.
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