4.7 Article

Absorption, Pharmacokinetics, and Safety of Triclosan after Dermal Administration

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 54, Issue 1, Pages 570-572

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00615-09

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Funding

  1. Infectopharm

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We evaluated the pharmacokinetics and safety of the antimicrobial agent triclosan after dermal application of a 2% triclosan-containing cream to six volunteers. Percutaneous absorption calculated from urinary excretion was 5.9% +/- 2.1% of the dose (mean +/- standard deviation). The amount absorbed suggests that daily application of a standard adult dose would result in a systemic exposure 890 times lower than the relevant no-observed-adverse-effect level. Triclosan can be considered safe for use in hydrophobic creams.

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