Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 52, Issue 12, Pages 4486-4491Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00222-08
Keywords
-
Categories
Funding
- anadian Institutes of Health Research
- Canadian Cystic Fibrosis Foundation (CCFF)
- CIHR-UBC TRID
- Juergen Manchot Foundation
- German Cystic Fibrosis Association
- Canada Research Chair
Ask authors/readers for more resources
Pseudomonas aeruginosa offers substantial therapeutic challenges due to its high intrinsic resistance to many antibiotics and its propensity to develop mutational and/or adaptive resistance. The PA14 comprehensive mutant library was screened for mutants exhibiting either two-to eightfold increased susceptibilities (revealing genes involved in intrinsic resistance) or decreased susceptibilities (mutational resistance) to the fluoroquinolone ciprofloxacin. Thirty-five and 79 mutants with increased and decreased susceptibilities, respectively, were identified, as confirmed by broth dilution.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available