4.7 Article

Klebsiella pneumoniae OmpA Confers Resistance to Antimicrobial Peptides

Journal

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 1, Pages 298-302

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00657-08

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Funding

  1. Fondo de Investigacion Sanitaria [PI05/2311]
  2. Govern Balear

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A Klebsiella pneumoniae ompA mutant was more susceptible to antimicrobial peptides (APs) than the wild type. Susceptibility did not result from surface changes other than the absence of OmpA. Our data suggest that OmpA is implicated in the activation of yet-unknown systems dedicated to ameliorating AP cytotoxicity.

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