Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 52, Issue 6, Pages 2239-2241Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00009-08
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Funding
- Intramural NIH HHS Funding Source: Medline
- NIAID NIH HHS [2R44AI052894-02, R44 AI052894] Funding Source: Medline
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We evaluated the in vivo efficacy of three beta-cyclodextrin derivatives that block the anthrax protective antigen pore. These compounds were at least 15-fold more potent than previously described beta-cyclodextrins in protecting against anthrax lethal toxin in a rat model. One of the drugs was shown to protect mice from bacterial infection.
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