Journal
MOLECULAR DIVERSITY
Volume 9, Issue 4, Pages 301-303Publisher
SPRINGER
DOI: 10.1007/s11030-005-2480-6
Keywords
ring-closing metathesis; ruthenium byproducts; polymer-bound triphenylphosphine oxide; silica gel; dimethyl sulfoxide
Categories
Funding
- National Cancer Institute [CA84173]
Ask authors/readers for more resources
Ruthenium byproducts from ring-closing metathesis reactions can be removed by refluxing the crude reaction mixture with resin-bound triphenylphosphine oxide (TPPO) in toluene or by stirring with dimethyl sulfoxide (DMSO) and silica gel at room temperature. Residual levels of ruthenium can be achieved that are as low as 0.04 mu g per 5 mg of product when a combination of TPPO, DMSO, and silica gel is used. The polymer-bound TPPO retained its efficiency after being recycled six times.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available