Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 53, Issue 3, Pages 876-882Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00946-08
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Funding
- Ministere de l'Education Nationale et de la Recherche [UPRES-EA3539]
- Universite Paris XI, Paris, France
- European Community [6th PCRD, DRESP2, LSHM-CT-2005-018705]
- Ministerio de Educacion y Ciencia [2007/0292]
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Chromosomally encoded beta-lactamases from the Burkholderia cepacia complex species (formerly Pseudomonas cepacia) were characterized. Cloning and sequencing identified an Ambler class A beta-lactamase (PenB) from B. cenocepacia. It shares 82% amino acid identity with the PenA beta-lactamases previously identified from B. multivorans 249. Its expression was dependent upon a LysR-type regulatory protein. Its narrow-spectrum hydrolysis activity mostly included penicillins but also included expanded-spectrum cephalosporins and aztreonam at lower levels. In that study, Pen-like beta-lactamases (PenC, PenD, PenE, PenF) that shared 63 to 92% identity with PenB from B. cenocepacia were identified from other Burkholderia species. The corresponding beta-lactamase genes might be used as genetic tools for accurate Burkholderia species identification.
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